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The 33rd ESMO Congress in Stockholm will present a rich and diversified programme, providing an update on progress in translational research and oncology practice, and presenting the latest developments in drugs and therapeutics
The 33rd Congress of the European Society for Medical Oncology (ESMO) will be held at the Stockholm International Fair in Alvsjo, Stockholm, Sweden, from 12 to 16 September 2008.
The congress will present a rich and diversified programme
with keynote lectures, educational, challenge-your-expert and controversy sessions, special and joint symposia, patient-case sessions and, for young oncologists, a masterclass, forum and
Scientific results submitted for presentations during the Congress in Stockholm span 23 different categories, and highlight the progress in translational research and medical oncology practice that scientists and practitioners face in the most progressive field of medicine. Incorporating the latest
developments in drugs and therapeutics will lead to some important changes in everyday clinical practice, including a better understanding of the need for more collaboration in cancer research and an integrated multidisciplinary approach to the treatment of patients.
Dr C Manegold from Heidelberg University Medical Centre, Germany, on behalf of an international study team, will present results of BO17704 (AVAIL), a double-blind trial that randomised 1,043 patients to cisplatin/gemcitabine for up to six cycles adding either bevacizumab (7.5mg/kg or 15mg/kg) or placebo, administered until disease progression in patients with histologically or cytologically documented untreated locally advanced, metastatic or recurrent nonsquamous, nonsmall-cell lung cancer (NSCLC). In their presentation, the authors will demonstrate data of the longer follow-up study of firstline
bevacizumab therapy with the primary endpoint as progression-free survival, and the secondary endpoints regarding overall survival, response rates, duration of response and safety.
Dr T Mok from the Chinese University of Hong Kong will present results on efficacy, symptom improvement and tolerability of the IRESSA Pan Asia Study (IPASS), a randomised, open-label, firstline study of gefitinib versus carboplatin/paclitaxel conducted in chemo-naive, never or light ex-smokers with good performance status, adenocarcinoma histology and stage IIIB/IV NSCLC. Exploratory endpoints included the association of different outcomes according to the epidermal growth factor
receptor mutation status.
Dr R Midgley, on behalf of the VICTOR Trial Group, will give an overview of the results of a phase III randomised, placebo-controlled double-blind trial of rofecoxib in patients after potentially curative surgery and completion of adjuvant therapy for stage II/III colorectal cancer. While the trial was planned
so that 7,000 patients received 25mg of rofecoxib daily or an identical placebo for two or five years, it unfortunately had to be terminated early due to the worldwide withdrawal of rofecoxib. Authors will present the data for the preplanned event-driven
interim analysis for the 1,167 patients who received rofecoxib and the 1,160 patients on placebo. Furthermore, the researchers extracted genomic DNA from 939 VICTOR patients. Following the characterisation of linkage disequilibrium across the PTGS2 (COX-2) gene, study investigators will discuss whether COX-2 genotyping might identify a subgroup of
Dr Bradley Monk from the University of California, Irvine, USA, will present the results of a large trial in recurrent ovarian cancer. A total of 672 patients were randomised in the phase III study of trabectedin with pegylated liposomal doxorubicin
(PLD), versus PLD only. This multicentre study was designed to establish clinical activity of a nonplatinum-based doublet therapy for second-line recurrent ovarian cancer. The study compared efficacy and safety of trabectedin in patients relapsing within, or
beyond, a platinum-free interval of six months since completion of first-line therapy.
Dr SM Lee, on behalf of Medical Research Council BR12 Collaborators and NCRI Brain Tumour Clinical Studies Group, UK, will present the results of the first randomised comparison of procarbazine, CCNU and vincristine versus temozolomide subrandomised between two different schedules (five-day
or 21-day) in chemo-naive patients with radiologically confirmed, recurrent high-grade glioma. The presentation will challenge the current understanding of temozolomide scheduling and dose intensity.
Dr R James from Maidstone General Hospital, UK, will discuss the long-term outcome of the UKCCCR randomised trial for chemoradiation in the treatment of epidermoid anal cancer. A total of 577 eligible patients were recruited; 285 patients received radiotherapy, and 292 received the same radiotherapy
combined with 5-fluorouracil during the first and final weeks of radiotherapy, and Mitomycin C on day 1. The study investigators will discuss the magnitude of the benefits seen over the first few years compared with the results 12 years later.
Dr P Schoffski from the University Hospital in Leuven, Belgium, will present the results of the phase III trial of sunitinib in imatinib-resistant/intolerant gastrointestinal stromal tumour patients. The results of rank-preserving structural failure time analysis will provide long-term OS data in 243 randomised
patients (sunitinib versus placebo) with implications for other crossover trials. Authors will also present safety data for long-term treatment.
Dr J Droney from the Royal Marsden Hospital/Imperial College London, UK, will provide a platform for a greater understanding of the pharmacogenomics of opioids. A total of 299 patients taking oral morphine for cancer pain were included in the first study to examine the effects of genetic variation in all three
opioid-receptor genes on analgesic response to morphine. Authors will show the association between polymorphisms in mu, delta and kappa opioid receptors with interindividual variation in analgesic response to morphine for cancer pain.
Some of the highlights that will be presented during the ESMO Congress 2008 will include:
A webcast, virtual meeting and summary report will be available on the ESMO website after the congress. Please visit: www.esmo.org